Journal Club : Gonadal mosaicism and transmission of genomic variants to the offspring

Date: 26 Oct 2020

Date: October 26th 2020, 13:00

Presentation: Stylianos Antonarakis

Topic: Gonadal mosaicism and transmission of genomic variants to the offspring

Reference(s): Xiaoxu Yang et al.,  … Joseph G. Gleeson, Temporal stability of human sperm mosaic mutations results in life-long threat of transmission to offspring, doi:  https://doi.org/10.1101/2020.10.14.339796, Posted in biorxiv 14oct20

Thomas A Sasani, Brent S Pedersen, Ziyue Gao, Lisa Baird, Molly Przeworski, Lynn B Jorde, Aaron R Quinlan, Elife. 2019 Sep 24;8:e46922. doi: 10.7554/eLife.46922., Large, three-generation human families reveal post-zygotic mosaicism and variability in germline mutation accumulation, PMID: 31549960

C STERN, A mosaic of Drosophila consisting of 1X, 2X and 3X tissue and its probable origin by mitotic non-disjunction, Nature 1960 Apr 9;186:179-80. doi: 10.1038/186179b0., PMID: 13834426